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Rhogam / Anti-D shot during pregnancy at 28 weeks? doctors? Babymom34 Due April 29 (girl); Temperance, MI, United States 12 posts
Nov 23rd '13

I have researched the Rhogam / Anti-D shot. I am currently pregnant and am O- Neg blood type. I had the RHD genotype test done (via my blood) to test the fetal blood type. The fetus blood type tested as positive. I understand the Rhogam is "routinely" given to all RH - mothers at 28 weeks. If you have a healthy pregnancy, but all of a sudden an accident happens or trauma that caused bleeding before 28 weeks which would require you to go into the hospital immediately and get and the Rhogram shot, I'm wondering what does the Rhogram shot actually do to help the current baby.

This is my first pregnancy. I am still a little uncertain if bleeding occurs and you go into the hospital to get the Anti D shot, what and how does it help the current child (who is positive) in relation to the blood mixing? I have read in literature it only works by protecting your next pregnancy and has nothing to do with the current pregnancy. So I'm a little confused if trauma happens and I were to get the shot, what does it actually do for the current child, and will and how does help the current child the mothers blood (RH- and babies blood RH+) were to mix?









*~*K_Nicole*~* Due July 5; 3 kids; 1 angel baby; Nowhere, CA, United States 3473 posts
Nov 23rd '13

I myself am RH- and only 8weeks with number 4. I just had rhogam two weeks ago for bleeding. Now from what I understand is that it does help the current baby. With my last baby I had a ton of spotting and bleeding and received rhogam 4times (once was after I delivered) with bby 2 I had it twice whole pregnant once after delivery and bby 1 only at 28w then after delivery. All of my children have positive blood types. My husband is also a positive blood type. Now I was told if my husband was negative like me I wouldn't need rhogam I don't know how true that is it came from a woman who told me
my pregnancy was eptopic and tried to have mE abort my baby all because she couldn't see anything during an ultrasound. Well she was wrong there is a perfect fly healthy 8w embryo inside me. I've beentold
so many things I just take the nasty shot LoL it's my least favorite thing about being pregnant

*~*K_Nicole*~* Due July 5; 3 kids; 1 angel baby; Nowhere, CA, United States 3473 posts
Nov 23rd '13

Oh and from what I hear is it helps because it keeps your body from attacking the positive blood type. Your body can build up antibodies to attack the blood or something like that LoL it's been so long since I've researched it and informed myself I forget it all

Babymom34 Due April 29 (girl); Temperance, MI, United States 12 posts
Nov 23rd '13

Hello

Thank you for your replies. :) Are you sure the Rhogam / Anti-D shot is given to protect the current pregnancy when trauma happens? How does it exactly? Does anyone have any references/ links in regards to this? As I have stated, from what I read it only is given to protect future babies which makes it difficult to understand how it would work for the current baby if trauma where to happen and I had to get the emergency Rhogam/ Anti -D shot.


But still left with a few questions. Also they say "it doesn't affect your first" (the RH factor) I'm wondering why it doesn't affect your first and more info on that, but can't find any online :o

Also, if anyone is interested reading this article here is the link. I found this very informative :)
http://sarawickham.files.wordpress.com/2011/10/a1e-routine-antenatal-anti-d-an-overview-of-the-evidence.pdf

BunnyGirl19 6 kids; 10 angel babies; Oregon 18539 posts
Nov 23rd '13

It protects the current pregnancy as well since if blood mixes during pregnancy you'll develop antibodies and that can harm current baby as well as future babies depending on where you are at in pregnancy and how aggressively your body responds to the blood mixing.

*~*K_Nicole*~* Due July 5; 3 kids; 1 angel baby; Nowhere, CA, United States 3473 posts
Nov 24th '13

It is given at 28 weeks because rhogam is only suppose to be given in 12week periods so at 28 weeks 12 weeks later is 40weeks and delivery you are also given it after delivery before discharge from the hospital. I have had multiple episodes of bleeding during pregnancy and they do not give it to me everytime I bleed they look
to see how long it's been and how significant it is. I also had to have it after having a CVS because obviously mIne and babys blood were probably mixed during the procedure

*~*K_Nicole*~* Due July 5; 3 kids; 1 angel baby; Nowhere, CA, United States 3473 posts
Nov 24th '13

They also say that 90+% of mom
who develop anti D develop it after 29weeks which is another reason it is given at 28 weeks to prevent that

Babymom34 Due April 29 (girl); Temperance, MI, United States 12 posts
Nov 24th '13

Quoting Marley, Sunny & Colts' Mo:
They also say that 90+% of mom
who develop anti D develop it after 29weeks which is another reason it is given at 28 weeks to prevent that



Hello
Thanks for your response. What would be the reasons why (medical terms), or statistics on how many women develop anti D after 29 weeks?

Ps. I do understand you have to get the shot as routine after an amnio and CVS.

Babymom34 Due April 29 (girl); Temperance, MI, United States 12 posts
Nov 24th '13

Quoting Mommy Sparky:
I am still going to look for articles about protection of the first (i think it would mainly be in multiple trauma scenarios, so 1 in a bagillion) but I did want to add: The main reason they give rhogam during pregnancy is if your blood mixes at some point and your body becomes sensitive to the protein there is no way to undo it. Rhogam will not protect any future little ones and you would be a high risk pregnancy.

eta: why they pick 28 weeks? Not sure yet. Probably considered safest in the last tri.




hello

Thank you that is much appreciated! I hope you are able to find some articles on it.

Rhogam is a blood product which is pooled. It is actually a blood product from RH - mothers along with sensitizing their blood. Hence, the Rhogam shot.

While I have done research and understand the general how Rhogam works. My question is more specific with this scenario. It is sort of confusing to me how it actually works in a trauma situation where the mothers blood (negative) has mixed with the babies blood (positive). Within 72 hours the shot is given. If trauma has happened within those 72 hours and the blood has already mixed, how will the Rhogam shot help prevent what has already started? I do understand it works similar to a "flu shot" injecting just enough so your body fights it off. But if the blood has already mixed within 72 hours or even after 5 hours if trauma has happened where the blood is confirmed to have mixed and my blood is already "attacking" the fetus, I'm not understanding how the Rhogam shot would help the current baby exactly?





Mandhee Dhandapani 2 kids; Houston, Texas 574 posts
Nov 24th '13

i too have to take it since i am negative an husband is positive...it helps your body not produce any antibodies against your baby ...with out it ..your body will start to produce antibodies against the baby thinking its a virus invading it ...when that happens first baby will be ok at time second some have needed blood transfusion because of poisoned blood ...after your first your chances of having a spontaneous abortion (miscarriage) and still birth goes up ...some dr only recommend having two children ...but to prevent all the bad from happening they give you the rhogam to stop the that from happening ...an for bleeding it just depends on were its coming from ....

*~*K_Nicole*~* Due July 5; 3 kids; 1 angel baby; Nowhere, CA, United States 3473 posts
Nov 24th '13

Quoting Babymom34:

Hello
Thanks for your response. What would be the reasons why (medical terms), or statistics on how many women develop anti D after 29 weeks?

Ps. I do understand you have to get the shot as routine after an amnio and CVS.




92% of woman will develop it at or after 28weeks. And no you do NOT have to get after an amino. Now a CVS is where they go in like a Pap smear and remove a sample of babies placenta to test for genetic defects which obviously can cause bleeding and mine and baby's blood
to mix.

Babymom34 Due April 29 (girl); Temperance, MI, United States 12 posts
Nov 24th '13

Quoting Marley, Sunny & Colts' Mo:

92% of woman will develop it at or after 28weeks. And no you do NOT have to get after an amino. Now a CVS is where they go in like a Pap smear and remove a sample of babies placenta to test for genetic defects which obviously can cause bleeding and mine and baby's blood
to mix.



No, you still have to get Rhogam after an amnio as their is a risk of the blood mixing considering a needle is inserted through the mother's abdominal wall, then through the wall of the uterus, and finally into the amniotic sac

Their are two methods how a CVS is done. Either the transcervical method or transabdominal. Amnio is done via transabdominal. Each method either Transabdominal or transcervical poses a risk for blood mixing which my doctor advised I would have to have Rhogam for a CVS or amnio no matter what method which makes sense. In addition to the small misscarriage risk, that is why I opted out for the CVS and Amnio. I had the RHd Genotype test (tests fetal blood type), MaterniT21, and Panoramic Test done (all screened though a blood test testing the mothers blood ) which are non invasive tests unlike the invasive CVS and amnio. They are highly accurate but not diagnostic.




*~*K_Nicole*~* Due July 5; 3 kids; 1 angel baby; Nowhere, CA, United States 3473 posts
Nov 24th '13

Quoting Babymom34:
No, you still have to get Rhogam after an amnio as their is a risk of the blood mixing considering a needle is inserted through the mother's abdominal wall, then through the wall of the uterus, and finally into the amniotic sac

Their are two methods how a CVS is done. Either the transcervical method or transabdominal. Amnio is done via transabdominal. Each method either Transabdominal or transcervical poses a risk for blood mixing which my doctor advised I would have to have Rhogam for a CVS or amnio no matter what method which makes sense. In addition to the small misscarriage risk, that is why I opted out for the CVS and Amnio. I had the RHd Genotype test (tests fetal blood type), MaterniT21, and Panoramic Test done (all screened though a blood test testing the mothers blood ) which are non invasive tests unlike the invasive CVS and amnio. They are highly accurate but not diagnostic.








I had the blood test also to check the baby's genetics my risk factors were very very low but my baby did in fact have a birth defect which is almost 100% of the time genetic so I had to have a CVS. I was never told I'd have to have rhogam after my amino had decided to have that at 16weeks instead of the cvs. I had it done at 12weeks back in April on the 25. My cvs was done through the cervix. I had no spotting right after but I did have it multiple times during that pregnancy. I ended up loosing that baby Aug 7 at 27w2d he was finally delivered after 26 1/2 he's of labor on Aug 8. Honestly having the rhogam is not a big deal and if it will help protect your future babies and possibly the one you're carrying now just have it. It's not worth the risk of your body developing antibodies to attack your fetus.

Babymom34 Due April 29 (girl); Temperance, MI, United States 12 posts
Nov 24th '13

Each RhoGam injected contains blood serum pooled from several different
persons with the antibodies. The manufacturer can not possibly screen or
remove all viruses from it. A single outbreak of hepatictis C occurred in 2533 Irish women who had received contaminated anti-D. Did you know the HIV anitbody has also been transmitted through anti-D? Four contaminated batches were found to be HIV-anitbody positive, and wo batches where described as "indeterminate". Where transmission of HIV and anti-D has occurred, it is quite possible that this contamination came from one blood donor; several batches may be contaminated because blood donations are pooled in order to make anti-D is truly essential to the manufacturing process, if this increases the chance of more women being infected. But that's a separate issue.


The problem is that injecting Rhogam during gestation you are getting
protection for your second pregnancy at the expense of your first. If you
put Rhogam antibodies into your body during your first pregnancy you are
putting antibodies against your baby into your blood stream where, if blood
mixing does occur, those antibodies will attack your baby. This is exactly
what you are trying to avoid for the second pregnancy. So, in reality you
are protecting your second pregnancy from the antibodies by injecting them
into yourself during the first pregnancy. I can't state it any better than
this: if you inject Rhogam durng your first pregnancy you will prevent a
potentially harmful situation for your next pregnancy by causing that exact
same harmful situation in your first pregnancy

REF: http://www.nccn.net/~wwithin/rhogam.htm


Nbeck Due March 9; 3 kids; Iowa 112 posts
Nov 24th '13

I had Rhogam for 3 pregnancies and my first was actually the smoothest of all. Just a personal experience but it obviously did not hurt my first daughter at all. She was born healthy, 9 lbs, has never had a health issue, and was moved ahead a grade because she was getting bored with the curriculum in her grade. My second and third pregnancies were hell and these kids have also had a lot more health issues, especially my last son. So IMO no it did not harm my first fetus and if it had any benefit for my second and third it was obviously worth it.